Primary Identifier | MGI:109619 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 11924 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables E-box binding activity. Involved in positive regulation of DNA-binding transcription factor activity. Acts upstream of or within several processes, including generation of neurons; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and integumental system. Orthologous to human NEUROG2 (neurogenin 2). PHENOTYPE: Homozygous null mice die after birth and have neuronal differentiation defects, affecting retinal development, spinal cord interneuron development and behavior. [provided by MGI curators] |