| Primary Identifier | MGI:2442120 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 242248 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable enzyme binding activity; signaling adaptor activity; and signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of B cell activation; negative regulation of gene expression; and regulation of intracellular signal transduction. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autoimmune disease (multiple) and systemic scleroderma (multiple). Orthologous to human BANK1 (B cell scaffold protein with ankyrin repeats 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased germinal center formation and IgM production in response to T-dependent antigens, and show enhanced CD40-mediated B cell proliferative and survival responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
