| Primary Identifier | MGI:87921 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 11522 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables all-trans-retinol dehydrogenase (NAD+) activity and identical protein binding activity. Acts upstream of or within several processes, including behavioral response to ethanol; ethanol catabolic process; and retinoid metabolic process. Located in mitochondrion. Is expressed in several structures, including endocrine gland; epidermis; genitourinary system; intestine; and sensory organ. Human ortholog(s) of this gene implicated in alcohol dependence; late onset Parkinson's disease; and pancreatic cancer. Orthologous to human ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide). PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired metabolism of (and sensitivity to) ethanol and retinol. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
