| Primary Identifier | MGI:1927489 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 56376 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin binding activity; muscle alpha-actinin binding activity; and protein kinase C binding activity. Predicted to be involved in actin cytoskeleton organization; cell growth involved in cardiac muscle cell development; and regulation of synapse organization. Located in Z disc. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb mesenchyme; and musculoskeletal system. Used to study dilated cardiomyopathy. Orthologous to human PDLIM5 (PDZ and LIM domain 5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired cardiac muscle contractility, wider Z-lines, and dilated cardiomyopathy. Mice heterozygous for a gene trap allele exhibit impaired response to methamphetamine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
