| Primary Identifier | MGI:109360 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 16911 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and positive regulation of kinase activity. Acts upstream of or within several processes, including cell differentiation in spinal cord; thymus development; and ventricular septum development. Located in cell leading edge and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study anencephaly. Orthologous to human LMO4 (LIM domain only 4). PHENOTYPE: Homozygous null mice die embryonically and exhibit a failure of neural tube closure and exencephaly, which is associated with abnormal patterns of cell proliferation and with high levels of apoptosis within the neuroepithelium. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
