| Primary Identifier | MGI:1859730 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 54673 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables fatty acid binding activity; lysophosphatidic acid acyltransferase activity; and phosphatidylinositol 3-kinase activator activity. Involved in several processes, including autophagic cell death; positive regulation of autophagosome assembly; and regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Acts upstream of or within 'de novo' post-translational protein folding; phosphatidic acid biosynthetic process; and positive regulation of establishment of protein localization to mitochondrion. Located in membrane. Part of protein-containing complex. Is expressed in several structures, including cerebellum; cerebral cortex; otocyst; and spleen. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1). PHENOTYPE: Homozygous mutation of this gene results in delayed apoptosis of embryonic fibroblasts in response to serum withdrawal or treatment with a mitochondrial stress inducer. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
