Primary Identifier | MGI:2139714 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 99633 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor activity and PDZ domain binding activity. Involved in synapse organization. Acts upstream of or within positive regulation of synapse assembly and response to bacterium. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in central nervous system; future brain; and heart. Orthologous to human ADGRL2 (adhesion G protein-coupled receptor L2). PHENOTYPE: Homozygous null mice die prenatally at fetal stages with cardiac defects. Heterozygous mice exhibit decreased locomotor activity in an open field test. [provided by MGI curators] |