| Primary Identifier | MGI:1096343 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 16875 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including female gonad development; forebrain neuron development; and odontogenesis of dentin-containing tooth. Located in female germ cell nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and respiratory system. Orthologous to human LHX8 (LIM homeobox 8). PHENOTYPE: Nullizygous mice exhibit a cleft palate with partial penetrance and die neonatally; those without cleft palate survive to adulthood. All mice show defective cholinergic neuron development. Females show autophagy of oocytes associated with DNA damage, ovary fibrosis, and premature ovarian failure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
