| Primary Identifier | MGI:2443276 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 435766 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein serine/threonine kinase activity. Involved in regulation of cardiac conduction and regulation of heart rate. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to several human genes including TNNI3K (TNNI3 interacting kinase). PHENOTYPE: Mice homozygous for a conditional allele activated in cardiac myocytes exhibit decreased response to cardiac ischemic/reperfusion injury. A strain-specific splicing allele (knockout) is protective against specific induced cardiopathies but has a negative effect on some heart parameters and on glucose metabolism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
