| Primary Identifier | MGI:1341864 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 18201 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable signaling adaptor activity and sphingomyelin phosphodiesterase activator activity. Involved in positive regulation of amide metabolic process; regulation of lipid metabolic process; and tumor necrosis factor-mediated signaling pathway. Predicted to be active in plasma membrane. Is expressed in genitourinary system and thalamus mantle layer. Orthologous to human NSMAF (neutral sphingomyelinase activation associated factor). PHENOTYPE: Mice homozygous for a targeted null mutation show no gross phenotypic abnormalities but display delayed cutaneous barrier repair. In addition, D-galactosamine-sensitized homozygotes are partially resistant to LPS- and TNF-induced lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
