| Primary Identifier | MGI:2181659 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 252838 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; cerebral cortex neuron differentiation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development; lymphocyte differentiation; and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). PHENOTYPE: Mice homozygous for a knock-out allele have a severe block in thymic positive selection leading to loss of CD4 T lineage cells, and display decreased NK cell numbers, severely reduced numbers of lymphoid tissue inducer cells, absence of all peripheral lymph nodes, and loss of Peyer's patches. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
