| Primary Identifier | MGI:2140359 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 100201 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of osteoblast differentiation; and positive regulation of fat cell differentiation. Acts upstream of or within several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum. Is expressed in several structures, including brain; head mesenchyme; retina nuclear layer; thymus primordium; and vibrissa. Orthologous to human TMEM64 (transmembrane protein 64). PHENOTYPE: Mice homozygous for a gene trap allele exhibit impaired osteoclast differentiation, enhanced osteoblast differentiation and increased bone mass. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
