| Primary Identifier | MGI:1891456 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 192656 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to muramyl dipeptide; immune response-activating signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of signal transduction; and response to bacterium. Predicted to be located in cytoskeleton; cytosol; and vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human RIPK2 (receptor interacting serine/threonine kinase 2). PHENOTYPE: Homozygous inactivation of this gene leads to impaired cytokine production in response to LPS treatment, and may result in resistance to LPS-induced septic shock and defects in Toll-like receptor and T-cell receptor signaling. Macrophages homozygous for a knock-in allele show normal LPS signaling. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
