Primary Identifier | MGI:95276 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 13841 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chemorepellent activity; growth factor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including ephrin receptor signaling pathway; negative regulation of nervous system development; and regulation of protein metabolic process. Acts upstream of or within nephric duct morphogenesis; nervous system development; and positive regulation of neuron apoptotic process. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; foot bone; genitourinary system; and sensory organ. Orthologous to human EPHA7 (EPH receptor A7). PHENOTYPE: Some homozygous mutants display anencephaly. Mutants also exhibit increased proliferation of neural progenitor cells in the lateral ventricle wall of the adult brain. [provided by MGI curators] |