| Primary Identifier | MGI:104615 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12801 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cannabinoid receptor activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within axonal fasciculation and glucose homeostasis. Located in growth cone. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1). PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors, altered long term depression and susceptibility to induced seizure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
