Primary Identifier | MGI:88390 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 12640 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable follicle-stimulating hormone activity. Acts upstream of or within several processes, including gonadotropin secretion; thyroid gland development; and thyroid hormone generation. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in extracellular space. Is expressed in brain; future pituitary; and retina nuclear layer. Orthologous to human CGA (glycoprotein hormones, alpha polypeptide). PHENOTYPE: Homozygous null mutants exhibit male and female sterility with hypogonadism, dwarfism, hypothyroidism, and both hypertrophy and hyperplasia of pituitary thyrotropes. [provided by MGI curators] |