| Primary Identifier | MGI:1333883 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 16798 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables protein serine/threonine kinase activity. Involved in hormone-mediated signaling pathway; negative regulation of protein localization to nucleus; and regulation of signal transduction. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Predicted to be located in centrosome; midbody; and spindle. Predicted to be active in several cellular components, including glutamatergic synapse; microtubule cytoskeleton; and postsynapse. Is expressed in several structures, including 2-cell stage conceptus; 8-cell stage conceptus; central nervous system; foregut-midgut junction; and otocyst. Orthologous to human LATS1 (large tumor suppressor kinase 1). PHENOTYPE: Homozygotes for a targeted null mutation exhibit high postnatal mortality, lack of mammary development, infertility, pituitary hyperplasia, reduced hormone levels, growth retardation, and susceptibility to sarcomas and ovarian stromal cell tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
