Primary Identifier | MGI:1916888 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 69638 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables hormone activity. Acts upstream of or within positive regulation of Notch signaling pathway. Located in plasma membrane. Is expressed in ductus deferens; epididymis; esophagus; ileum; and prostate gland. Orthologous to human ENHO (energy homeostasis associated). PHENOTYPE: Mice homozygous for a null allele show reduced locomotor activity and impaired coordination. Mice homozygous for a different null allele display partial preweaning lethality, increased adiposity, dyslipidemia, hypoactivity and insulin resistance on a chow diet, as well as increased severity of impaired glucose tolerance and hepatic steatosis after high-fat feeding. [provided by MGI curators] |