| Primary Identifier | MGI:2447188 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 230099 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable carbonate dehydratase activity; molecular function activator activity; and zinc ion binding activity. Acts upstream of or within morphogenesis of an epithelium and secretion. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; gut; and heart. Human ortholog(s) of this gene implicated in hepatitis B; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human CA9 (carbonic anhydrase 9). PHENOTYPE: Mice homozygous for a targeted mutation are viable and fertile but develop hyperplasia of the glandular gastric epithelium with numerous cysts. Mice homozygous for a different mutation show an increased mean percentage of mature B cells in bone marrow. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
