| Primary Identifier | MGI:98810 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 22004 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATP-dependent activity. Predicted to be located in actin cytoskeleton. Predicted to be part of muscle thin filament tropomyosin. Predicted to be active in actin filament. Is expressed in several structures, including cochlea; lateral plate mesoderm; musculature; retina; and urinary system. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2). PHENOTYPE: Homozygous mice for a null allele exhibit embryonic lethality. Heterozygotes develop cataracts and show impaired healing of lens wounds. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
