| Primary Identifier | MGI:1099832 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 21894 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables integrin binding activity; phosphatidylinositol binding activity; and phosphatidylserine binding activity. Involved in cortical microtubule organization; integrin activation; and integrin-mediated signaling pathway. Acts upstream of or within cell-substrate junction assembly and cortical actin cytoskeleton organization. Located in focal adhesion. Is expressed in several structures, including body cavity or lining; cardiovascular system; nervous system; submandibular gland; and vertebral axis musculature. Orthologous to human TLN1 (talin 1). PHENOTYPE: Mice homozygous for either one of two knock-out alleles display early developmental anomalies, reduced embryo size, and embryonic lethality due to impaired cell migration at the gastrulation stage. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
