| Primary Identifier | MGI:99946 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12913 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of chemotaxis; positive regulation of deacetylase activity; and regulation of DNA-templated transcription. Predicted to be located in several cellular components, including Golgi membrane; neuronal cell body; and nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and skeleton. Orthologous to human CREB3 (cAMP responsive element binding protein 3). PHENOTYPE: Mice homozygous for a knock-out allele are sub-viable. Heterozygotes are resistant to high-fat diet-induced obesity and hepatic steatosis and show increased energy expenditure and respiratory exchange ratios, altered hepatic lipid profiles, but maintain normal glucose levels on a high-fat diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
