| Primary Identifier | MGI:1855698 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 53614 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables Wnt-protein binding activity; coreceptor activity; and endopeptidase inhibitor activity. Involved in several processes, including negative regulation of metalloendopeptidase activity; positive regulation of canonical Wnt signaling pathway; and regulation of establishment of blood-brain barrier. Acts upstream of or within several processes, including blood vessel maturation; embryo implantation; and embryonic forelimb morphogenesis. Located in plasma membrane. Part of Wnt signalosome. Is expressed in several structures, including Meckel's cartilage; diaphragm; genitourinary system; and musculoskeletal system. Orthologous to human RECK (reversion inducing cysteine rich protein with kazal motifs). PHENOTYPE: Homozygous mutation of this gene results in lethality around E10.5-E11.5, defects in collagen fibrils, basal lamina and vascular development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
