| Primary Identifier | MGI:894297 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12757 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTPase binding activity; clathrin heavy chain binding activity; and peptide binding activity. Predicted to be involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in cytoplasmic vesicle. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human CLTA (clathrin light chain A). PHENOTYPE: Homozygous null mice exhibit an enhanced isotype switch to IgA production, abnormal synaptic vesicle recycling, a reduced synaptic vesicle pool, impaired neurotransmission, and deficits in motor coordination. About 50% die within a week of birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
