| Primary Identifier | MGI:98294 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 230126 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables signaling receptor complex adaptor activity. Acts upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Is expressed in brain; molar; and sensory organ. Orthologous to human SHB (SH2 domain containing adaptor protein B). PHENOTYPE: Mice homozygous for a null allele exhibit some embryonic lethality associated with various embryogenesis defects including loss of embryo structures, open neural tube, hemorrhaging and tail defects. Heterozygous mice exhibit a distortion in the transmission ratio of the allele maternally. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
