| Primary Identifier | MGI:1925927 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 109331 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and histone H2B C-terminal K residue ubiquitin ligase activity. Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20). PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete preimplantation embryonic lethality. Heterozygotes are predisposed to acute and chronic colonic inflammation and development of colorectal cancer. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
