| Primary Identifier | MGI:108429 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 14745 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). PHENOTYPE: Nullizygous mutations cause partial peri- and postnatal lethality, growth defects, craniofacial anomalies, and wide set eyes. Additional phenotypes include altered brain 5-HT and amino acids, reduced prepulse inhibition, impaired suckling, and increased apoptosis in sciatic nerve Schwann cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
