| Primary Identifier | MGI:1933378 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 59001 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including chromatin remodeling; leading strand elongation; and regulation of nucleobase-containing compound metabolic process. Located in pericentric heterochromatin. Is expressed in several structures, including alimentary system; cranium; genitourinary system; nervous system; and sensory organ. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). PHENOTYPE: Homozygous knockout affects thymocyte development and bone ossification leading to late embryonic lethality. Mutations changing the charge of the peptide tail from negative to positive affect B cell and T cell maturation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
