| Primary Identifier | MGI:101922 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 21923 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable fibronectin binding activity; integrin binding activity; and syndecan binding activity. Involved in several processes, including neuromuscular junction development; peripheral nervous system axon regeneration; and regulation of inflammatory response. Acts upstream of or within positive regulation of cell population proliferation; positive regulation of gene expression; and prostate gland development. Located in basement membrane; extracellular region; and interstitial matrix. Part of tenascin complex. Is active in perisynaptic extracellular matrix. Is expressed in several structures, including alimentary system; brain; heart and pericardium; immune system; and skeletal system. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C). PHENOTYPE: Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
