| Primary Identifier | MGI:96824 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 21898 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables lipopolysaccharide immune receptor activity. Involved in several processes, including positive regulation of defense response; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of biosynthetic process; and response to bacterium. Located in plasma membrane. Part of receptor complex. Is expressed in several structures, including brain; early embryo; genitourinary system; inner cell mass; and intestine. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4). PHENOTYPE: Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide (LPS) and more susceptible to infection by gram negative bacteria. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
