| Primary Identifier | MGI:1924054 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 76804 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme binding activity; histone H3K9 demethylase activity; and nuclear androgen receptor binding activity. Acts upstream of or within several processes, including blastocyst formation; regulation of stem cell differentiation; and stem cell population maintenance. Located in pericentric heterochromatin. Is expressed in several structures, including early conceptus; eye; genitourinary system; rib; and telencephalon. Human ortholog(s) of this gene implicated in autistic disorder; breast cancer; carcinoma (multiple); head and neck cancer; and withdrawal disorder. Orthologous to human KDM4C (lysine demethylase 4C). PHENOTYPE: Mice homozygous for a null gene trap allele cannot be produced likely due to embryonic lethality. Mice heterozygous for a null gene trap allele exhibit reduced body weight and lower incidence and multiplicity of both benign and malignant tumors in mice treated with DMBA and TPA. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
