Primary Identifier | MGI:2142116 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 101739 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including chromatin binding activity; supercoiled DNA binding activity; and transcription coactivator activity. Involved in response to heat and response to oxidative stress. Predicted to be located in chromatin and nuclear lumen. Predicted to be active in nucleus. Is expressed in several structures, including cerebral cortex; cranial ganglion; limb; limb bud; and sensory organ. Orthologous to human PSIP1 (PC4 and SRSF1 interacting protein 1). PHENOTYPE: Mice homozygous for disruptions in this gene tend to die perinatally. Survivors show reduced fertility and a variety of skeletal and behavioral abnormalities. [provided by MGI curators] |