| Primary Identifier | MGI:1915691 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 68441 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTP binding activity and GTPase activity. Involved in several processes, including glucose homeostasis; negative regulation of autophagy; and positive regulation of TOR signaling. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP; GATOR1 complex; and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human RRAGA (Ras related GTP binding A). PHENOTYPE: Mice homozygous for null mutations display embryonic lethality during organogenesis, impaired growth and open neural tubes. Mice homozygous for a constitutively active knock-in allele exhibit neonatal lethality associated with impaired hepatic gluconeogenesis and impaired autophagy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
