| Primary Identifier | MGI:107657 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 15977 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity and type I interferon receptor binding activity. Involved in several processes, including negative regulation of Lewy body formation; response to virus; and type I interferon-mediated signaling pathway. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; defense response to bacterium; and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19; cerebral infarction; multiple sclerosis; and retinoblastoma. Orthologous to human IFNB1 (interferon beta 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit enhanced proliferation and reduced TNF-alpha production by activated T lymphocytes, a defect in B cell maturation, fewer circulating granulocytes and macrophages, and increased viral susceptibility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
