| Primary Identifier | MGI:104737 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12579 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and spleen development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and liver. Human ortholog(s) of this gene implicated in carcinoma (multiple); erythema infectiosum; hematologic cancer (multiple); open-angle glaucoma; and urinary bladder cancer. Orthologous to human CDKN2B (cyclin dependent kinase inhibitor 2B). PHENOTYPE: Animals homozygous for a mutation in this gene exhibit increased tumor incidence, lymphoid hyperplasia, and extramedullary hematopoiesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
