| Primary Identifier | MGI:2140219 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 100061 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables signaling receptor activity. Involved in several processes, including host-mediated regulation of intestinal microbiota composition; positive regulation of canonical NF-kappaB signal transduction; and regulation of inflammatory response. Acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction and toll-like receptor signaling pathway. Located in plasma membrane. Orthologous to human LRRC19 (leucine rich repeat containing 19). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to uropathogenic E. coli infection with increased number and decreased clearance of bacteria, and reduced inflammatory response in the kidney. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
