| Primary Identifier | MGI:96646 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 16476 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to anisomycin and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; eyelid development in camera-type eye; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription factor AP-1 complex and transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; long bone; and sensory organ. Used to study psoriasis and pulmonary emphysema. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). PHENOTYPE: Null homozygotes die at midgestation with impaired hepatogenesis, altered fetal liver erythropoiesis and edema. A mutant replacing two serines by alanines is viable, fertile, small-sized and resistant to kainate-induced seizures and neuronal apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
