| Primary Identifier | MGI:1347473 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 15221 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in in utero embryonic development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor; embryonic placenta development; and trophectodermal cell differentiation. Predicted to be located in chromatin. Predicted to be part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human FOXD3 (forkhead box D3). PHENOTYPE: Mice homozygous for null alleles dsiplay embryonic lethality with failure of primitive streak formation and gastrulation and failure to derive cultures of embryonic or trophoblast stem cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
