Primary Identifier | MGI:2687005 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 230514 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus. Predicted to be active in endosome. Is expressed in central nervous system; heart valve; and retina nuclear layer. Orthologous to human LEPROT (leptin receptor overlapping transcript). PHENOTYPE: Mice homozygous for a null allele show reduced food intake and on a high fat diet show altered fat distribution and improved glucose tolerance and insulin sensitivity. [provided by MGI curators] |