Primary Identifier | MGI:1346085 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 23919 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within positive regulation of feeding behavior. Located in collagen-containing extracellular matrix. Is expressed in several structures, including adipose tissue; brain; gut; hemolymphoid system gland; and retina. Orthologous to human INSL5 (insulin like 5). PHENOTYPE: Mice homozygous for a targeted mutation display no abnormal phenotype. Mice homozygous for a different knock-out allele exhibit background sensitive reduction in fertility due to reduced sperm motility and irregular estrous cycle and impairment in glucose tolerance due to reduced insulin levels. [provided by MGI curators] |