| Primary Identifier | MGI:94896 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 13370 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables selenium binding activity and thyroxine 5'-deiodinase activity. Predicted to be involved in amino acid metabolic process and thyroid hormone metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including foregut; intestine; liver and biliary system; and metanephros. Human ortholog(s) of this gene implicated in thyroid gland disease. Orthologous to human DIO1 (iodothyronine deiodinase 1). PHENOTYPE: Mice homozygous for a disruption in this gene display elevated thyroxine (T4) and reverse triiodothyronine (rT3) levels and changes in the metabolism and excretion of iodothyronines. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
