| Primary Identifier | MGI:1201386 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 230598 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable peptidase activity. Involved in negative regulation of cold-induced thermogenesis; positive regulation of membrane protein ectodomain proteolysis; and regulation of nervous system development. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; nose; and spleen. Orthologous to human NRDC (nardilysin convertase). PHENOTYPE: Mice homozygous for a knock-out allele mostly die within 48 hours of birth with surviving mice exhibiting cortical thinning, enlarged lateral ventricles, hypomyelination, reduced grip strength, impaired coordination, and impaired spatial working memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
