| Primary Identifier | MGI:893580 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 19152 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including mature conventional dendritic cell differentiation; neutrophil extravasation; and positive regulation of GTPase activity. Predicted to be located in azurophil granule lumen; cytosol; and plasma membrane raft. Predicted to be active in extracellular region. Predicted to colocalize with plasma membrane. Is expressed in 2-cell stage conceptus; 8-cell stage conceptus; blastocyst-stage conceptus; liver; and morula-stage conceptus. Orthologous to human PRTN3 (proteinase 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit delayed neutrophil death and increased neutrophil accumulation at sites of inflammation in a murine model of peritonitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
