| Primary Identifier | MGI:105388 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12580 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity and negative regulation of stem cell proliferation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Used to study breast cancer. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C). PHENOTYPE: Homozygotes for targeted null mutations exhibit kidney and mammary gland cortical cysts, Leydig cell hyperplasia, reduced testosterone levels, late developing thymic lymphomas and pituitary tumors, gigantism, and organomegaly. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
