| Primary Identifier | MGI:1918244 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 78933 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in C-terminal protein deglutamylation; defense response to virus; and protein side chain deglutamylation. Acts upstream of or within several processes, including axonal transport of mitochondrion; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of blastocyst development. Located in cytosol. Is expressed in brain; early embryo; nose; and trigeminal ganglion. Orthologous to human AGBL4 (AGBL carboxypeptidase 4). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal platelet morphology and physiology, impaired megakaryopoiesis, increased spleen weight and increased susceptibility to HSV or VACV infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
