| Primary Identifier | MGI:2153518 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 140477 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in brain development; developmental growth; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within adult feeding behavior and adult locomotory behavior. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo ectoderm; limb bud; male reproductive gland or organ; and sensory organ. Orthologous to human DMBX1 (diencephalon/mesencephalon homeobox 1). PHENOTYPE: Mice homozygous for one null allele display partial postnatal lethality, impaired suckling and postnatal growth, and reduced female fertility. When raised in isolation, mice homozygous for another null allele exhibit decreased body weight, decreased food consumption, and small adipocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
