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Protein Coding Gene : Tmem53 transmembrane protein 53
Primary Identifier  MGI:1916027 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  68777
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in several processes, including negative regulation of BMP signaling pathway; negative regulation of ossification; and negative regulation of osteoblast differentiation. Located in nuclear outer membrane. Is expressed in chondrocranium; forelimb long bone; long bone epiphyseal plate; long bone epiphyseal plate proliferative zone; and periosteum. Used to study craniotubular dysplasia Ikegawa type. Human ortholog(s) of this gene implicated in craniotubular dysplasia Ikegawa type. Orthologous to human TMEM53 (transmembrane protein 53).
  • synonyms:
  • MGI:1923634,
  • 1700012A05Rik,
  • RIKEN cDNA 1500001P22 gene,
  • Tmem53,
  • MGI:1916223,
  • transmembrane protein 53,
  • RIKEN cDNA 1110038M16 gene,
  • 1500001P22Rik,
  • RIKEN cDNA 1700012A05 gene,
  • 1110038M16Rik
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Features --> Cross References

Genome

Sequence Feature Displayer

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4 Involved In Mutations

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0 Transgenic Expressors

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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