Primary Identifier | MGI:102695 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 19268 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chondroitin sulfate proteoglycan binding activity. Acts upstream of or within neuron projection regeneration and regulation of axon regeneration. Located in neuron projection and neuronal cell body. Is expressed in several structures, including adrenal gland; alimentary system epithelium; central nervous system; genitourinary system; and nasal cavity epithelium. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F). PHENOTYPE: Homozygous null females have premature involution of the mammary glands leading to an inability to feed pups. Other characteristics of null mice include defective nerve regeneration and hyperactivity. [provided by MGI curators] |