Primary Identifier | MGI:101896 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 18991 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity. Involved in positive regulation of DNA-templated transcription and positive regulation of gene expression. Acts upstream of or within forebrain development; keratinocyte differentiation; and myelination in peripheral nervous system. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; nervous system; sensory organ; and urinary system. Orthologous to human POU3F1 (POU class 3 homeobox 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit cyanosis and respiratory distress at birth and defective peripheral myelination due to arrested Scwann cell maturation. Mutants usually die at birth or shortly thereafter. [provided by MGI curators] |