| Primary Identifier | MGI:2183426 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 192199 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables heparin binding activity and signaling receptor binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including male meiotic nuclear division; positive regulation of non-canonical Wnt signaling pathway; and regulation of male germ cell proliferation. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; genitourinary system; and integumental system. Orthologous to human RSPO1 (R-spondin 1). PHENOTYPE: Homozygous inactivation of this gene leads to abnormal ovarian development and masculinized features including pseudohermaphroditism in genital ducts, depletion of fetal oocytes, male-like vascularization, and ectopic testosterone production in the ovaries. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
